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Live demoAATD Case-Finder — governed decision-support demo
Live prototype of how Eye4Health structures alpha-1 antitrypsin deficiency (AATD) testing prompts: enter clinical flags, see explainable outputs with rationale and next steps, and evidence-linked logic you can govern — all without storing identifiers.
Published: 27 April 2026
Updated: 27 April 2026
Decision-support demo
Explainable support
Each output shows why it triggered, with rationale and next steps.
Responsive by design
Web, tablet, and phone layouts for clinical and field settings.
Source-backed logic
Rules held in an explicit, versionable clinical pack — not buried in UI code.
Workflow-aware
Structured for specialist, market-access, and governance review.
Layout preview
Optional tablet and phone widths for stakeholder reviews. Full width remains the default.
Case assessment
Enter illustrative clinical flags. No identifiers are collected or stored. Gender is optional context only — it is not used when rules are evaluated in this demo.
Patient details
Smoking history
Family history
- First-degree relative with AATD
- Family history of COPD
- Family history of liver disease
Medical history
- COPD
- Asthma
- Adult-onset asthma
- Bronchiectasis
- Liver disease
- Unexplained liver disease
- Neonatal cholestasis
- Panniculitis
- Vasculitis
- Fixed airflow obstruction
- CT/clinical emphysema disproportionate to pack-years
Transparency: rules pack and thresholds
Prompts follow the versioned clinical rules delivered with the reference toolkit (ClinicalRules.json · Alpha-1-Companion/ClinicalRules.json). Key reference thresholds in that pack: serum AAT low trigger < 1.1 g/L; CRP inflammation context ≥ 10 mg/L. Those laboratory values are not entered in this prototype; they inform how rules are written in the reference workflow.
Prototype only. Outputs are decision-support prompts for professionals — not a diagnosis, not prescribing advice, and not a medical device. Follow local pathways, governance, and specialist input as usual.
The problem we are addressing
Alpha-1 antitrypsin deficiency remains under-recognised. Teams need disciplined prompts that surface when laboratory follow-up may be proportionate — without replacing clinical judgement.
What Eye4Health demonstrates here
- Maps clinical inputs to transparent if/then rules aligned with the Alpha-1 Companion reference toolkit.
- Lists every rule that fires, with rationale and next-step content carried through from the approved rule text — ranked by severity so teams can scan outcomes quickly.
- Keeps evaluation logic auditable (plain TypeScript, automated checks); no persistence or patient identifiers in this demo.
Governance, inputs, and related work
How the rules are sourced, what you can enter in this prototype, and where Eye4Health can extend the same approach — summarised below without crowding the experience above.
Inputs and rule pack
- Versioned clinical rules pack as shipped with the reference toolkit (thresholds and triggers used by this prototype).
- Age, smoking exposure (pack-years), and yes/no clinical and family-history toggles — nothing that identifies an individual is collected or stored.
Governance and appropriate use
- Showroom prototype: prompts support professional judgement — not diagnosis, prescribing, or a substitute for local policy.
- Rule wording and thresholds should be reviewed periodically against current guidance before any patient-facing use.
Related Eye4Health capabilities
- AATD prevalence — expected cases
Companion showroom view: population prevalence scenarios aligned to this programme.
- Epidemiology and market evaluation